International Review of Ophthalmology ›› 2014, Vol. 38 ›› Issue (6): 420-424.doi: 10.3760/ cma. j. issn.1673-5803.2014.06.013

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Role of nitric oxide in ocular diseases

CUI Hui， LI Gen-lin   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Lab. of Ophthalmology & Visual Sciences, Beijing 100730, China
  • Received:2014-05-12 Online:2014-12-22 Published:2014-12-26
  • Contact: LI Genlin, Email: ligenglin@263.net

Abstract: In  recent years it has been recognized that nitric oxide(NO) is a hot spot in research of ocular diseases. As a molecular medium synthesized by nitric oxide synthase (NOS). NO is involved in the control of ocular blood flow. Abnormalities of NO system have been observed in a variety of ocular diseases including uveitis, glaucoma, retinal ischemic diseases, diabetic retinopathy and retinitis pigmentosa. In addition, its antagonist endothelin1(ET1) also attracts much attention. All these make the nitric oxide pathway an attractive target for therapeutic interventions of ocular diseases.   (Int Rev Ophthalmol, 2014, 38:   420-424)